Black Box Warning Did Not Cause Increased Suicides

The black box warning for droperidol.

To the Editor:—I read with interest the recent article and accompanying editorial regarding the black box warning on the package insert for droperidol. Nuttall et al. indicate that droperidol is a safe, effective, and inexpensive antiemetic and that the black box warning on the package insert is not needed. In addition, they seem to believe that their use of droperidol is prevented by the prese...

A black-box warning for antidepressants in children?

Did insect pollination cause increased seed plant diversity?

The dominant paradigm for the disproportionate number of flowering plants is the unique coevolution that they underwent with pollinating insects. The theory underlying this biotic pollination hypothesis contradicts more generally accepted evolutionary theory. Furthermore, various lines of empirical evidence falsify the biotic pollination hypothesis: (a) several lineages of plants were insect po...

Does "isolation" cause jail suicides?

In their efforts to prevent suicides, psychiatrists who consult to jails face a terrible dilemma. Placing a suicidal inmate in a single cell to restrict access to harmful materials and instruments is a common practice. Yet, mental health authorities argue that isolating a suicidal inmate only fuels the flames of his self-destructive impulses. It behooves mental health professionals to advocate ...

Black-Box Composition Does Not Imply Adaptive Security

In trying to provide formal evidence that composition has security increasing properties, we ask if the composition of non-adaptively secure permutation generators necessarily produces adaptively secure generators. We show the existence of oracles relative to which there are non-adaptively secure permutation generators, but where the composition of such generators fail to achieve security again...